The Geiger lab

T cells are key players in the immune system with the ability to detect and eliminate infected cells and tumors. We study molecular regulations underlying T cell activation and anti-tumor activity. For this, we use a wide range of technologies including mass spectrometry-based proteomics, functional genomics, mouse models and microfluidics-based systems. Our projects aim to provide detailed insights into T cell functionality that can be translated into the clinic to improve anti-cancer immunotherapies.

 

Quantitative Molecular Analysis of the T cell Response

To explore molecular mechanisms underlying the T cell response, we use quantitative systems approaches including  mass spectrometry-based proteomics, RNA-Seq, ATAC-Seq as well as several targeted approaches.

Immune Response to Liver Cancer

We are interested in the immune response to liver cancer. T cells that infiltrate liver tumors are often exhausted and do not work properly. To potentially increase their functionality, we study the underlying regulations by systematically analyzing tumor-infiltrating T cells with high-resolution mass spectrometry and functional assays.

Rapid Identification of T cell Receptors that recognize Tumor Antigens

We develop workflows to efficiently isolate T cells that recognize liver tumor antigens. Tumor-reactive T cells can be grown to large numbers and used for adoptive T cell therapies, a highly personalized form of cancer therapy. In collaboration with the research group of Andrew deMello (ETH Zürich), we use droplet-based microfluidics systems to manipulate and analyze single T cells in a high-throughput format.

People

 
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Roger obtained his PhD from the ETH Zürich under the supervision of Prof. Ari Helenius. He received postdoctoral training in immunology with Prof. Antonio Lanzavecchia and in proteomics with Prof. Matthias Mann. Since 2017 Roger is an independent group leader at the IRB.

Principle Investigator

Roger Geiger, PhD

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Fernando obtained his PhD from the Universidad Nacional de Córdoba in Argentina where he worked on mechanisms contributing to T cell exhaustion in tumor-infiltrating CD8+ T cells. He joined the Geiger lab as a postdoctoral scholar in 2018.

Post-Doc

Fernando Canale, PhD 

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Gaia obtained her bachelor and master degrees from the University of Milan Bicocca. She was then a postgraduate fellow at Experimental Immunology Unit at San Raffaele Hospital, in Milano. 

PhD Student

Gaia Antonini

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Wenjie obtained his bachelor degree from Peking University and his master degree in pathology from the Case Western Reserve University.

PhD Student

Wenjie Jin

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Giada obtained her bachelor degree at the University of Varese. She then did her masters in Biology at the Institute of Oncology Research (IOR) before joining the Geiger lab in 2018.

PhD Student

Giada Zoppi

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Ian did his bachelor and master degrees at McGill University in Montréal, Canada. He then worked as a research associate at the University of California, San Francisco (UCSF) before joining the Geiger Lab in 2019 as a PhD student.

PhD Student

Ian Vogel

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Matteo obtained his PhD at the Universitat Autònoma de Barcelona. He then received postdoctoral training in the laboratory of Matthias Mann at the Max Planck Institute in Munich, Germany. He joined the Geiger lab in 2019 as a research specialist is mass-spectrometry based proteomics.

Matteo Pecoraro, PhD

Research Associate

Microfluidics Devices

We use droplet-based microfluidics devices that are developped in the laboratory of Professor deMello.

 

Selected publications

For a full list of publications:

 

Available Positions

 

Postdoctoral fellow positions

Applications are invited for a Post-Doctoral Fellow position in the ‘Systems Immunology’ research group led by Dr. Roger Geiger.

 

We welcome all applications from individuals who are passionate about applying new technologies to studying the immune response to tumors. Please contact Roger with your CV and a cover letter.

Collaborators

 

Surgeons

We collaborate with Prof. Ercolani from the University Hospital in Bologna, with PD Dr. Rahbari from the University Clinic in Mannheim and with Dr. Seifert and Prof. Chavakis from the University Hospital in Dresden.

Microfluidics

The microfluidics devices that we use in our project are developed in the research group of Prof. deMello at the ETH Zürich.

 
Funding

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